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However, appetite hormones (like ghrelin) may gradually rise again if GLP-1 medication is discontinued, which is why ongoing treatment supports long-term weight management

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Understanding these potential mechanisms helps clinicians counsel patients appropriately and distinguish between expected treatment effects and concerning adverse reactions

Similarly, the KDIGO 2024 CKD guideline recommends GLP-1 RAs for adults with T2DM and CKD who have not achieved individualized glycemic targets [21]

The different colorectal tumor risk related to GLP-1 receptor agonists and SGLT2 inhibitors use: a network meta-analysis of 68 randomized controlled trials